Warfarin
is an anticoagulant (blood thinner). It reduces the formation of blood clots. Also, it is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions.
Pharmacokinetics of warfarin
- Warfarin consists of a racemic mixture of two active enantiomers—R– and S– forms—each of which is cleared by different pathways.
- S-warfarin is 2–5 times more potent than the R-isomer in producing an anticoagulant response.
- Both the enantiomers of warfarin undergo CYP-mediated metabolism by many different CYPs to form 3′,4′,6,7,8 and 10-hydroxy warfarin metabolites, major being 7-OH warfarin formed from S-warfarin by CYP2C9 and 10-OH warfarin from R-warfarin by CYP3A4
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