WARFARIN effects
Warfarin effects is an anticoagulant (blood thinner). It reduces the formation of blood clots. Also, it treats or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions.
Pharmacokinetics of warfarin
- It consists of a racemic mixture of two active enantiomers—R– and S– forms—each of which is cleared by different pathways.
- S-isomer is 2–5 times more potent than the R-isomer in producing an anticoagulant response.
- Both the enantiomers of it undergo CYP-mediated metabolism. The metabolisms by many different CYPs to form 3′,4′,6,7,8 and 10-hydroxy warfarin metabolites. The major being 7-OH warfarin formed from S-isomer by CYP2C9 and 10-OH warfarin from R-warfarin by CYP3A4
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